Primary Neonatal Outcomes in the metformin and MNT group in Early Trimester with Early Gestational Glucose Intolerance
S. Agarwal1, S. Tiwari1, S. Verma1, P. Taneja1, S. Veeraswamy2, R. Jain3, P. Saxena4, A. Chandrasekar5, B.Natarajan6.1GSVM Medical College, Obstetrics and Gynaecology, Kanpur, India. 2The MGR Tamilnadu Medical University, Obstetrics and Gynecology, Chennai, India. 3 Jain Hospital & Research Centre Pvt Ltd, Medicine, Kanpur, India. 4 LHMC Medical College, Obstetrics and Gynaecology, New Delhi, India. 5 Madha Medical College and Research Institute, Obstetrics & Gynaecology, Chennai, India.6 SRC Diabetes Centre-, Diabetes, Erode, India
Abstract
Method
A study included pregnant women at 8 to 10 weeks of gestation, divided into two groups based on their blood sugar levels of≥110 mg/dl. Those with high levels ≥110 mg/dl received two different interventions: Metformin-MNT and MNT only. Follow-up outcomes were done until delivery.
Results
Primary Outcomes* The Adverse neonatal composite outcomes in the groups were 35 (37.6%) vs 55 (52.3), which were statistically significant (P = 0.038), but the Primary Maternal hypertension composite outcomes were not significant (9 (9.6%) vs 10 (10.7%), P = 0.80) (Table 1). IUD/Spontaneous abortion 8-28 Weeks and stillbirth are 20 (16) and 12(9.6) in the MNT Group compared to nil in the MNT-Metformin intervention group, which is highly significant.
Conclusion: It’s important to keep maternal 2-hour postprandial blood glucose (PPBG) levels below 110 mg/dL in the 10th week of pregnancy to prevent fetal hyperinsulinemia and improve maternal-fetal health.
