Safety and Efficacy of different Classes of Insulin as Add on Therapy of oral hypoglycemic agents in uncontrolled Type 2 Diabetes
Ashritha Kudikala1, Haripriya Kanaparthi, Mahibul Islam1, Satish Chinnala2
- Pharm.D Intern, Balaji Institute of Pharmaceutical Sciences, Laknepally, Warangal, Narsampet, India; 2. Associate Professor, Department of Clinical
Pharmacy, Balaji Institute of Pharmaceutical Sciences, Laknepally, Warangal, Narsampet, India. (Corresponding author)
[email protected]
Abstract
Aim: This study aims to evaluate the safety and efficacy of insulin as an adjunct therapy to one or More oral hypoglycaemic agents in patients with
uncontrolled type 2 diabetes (T2D).
Objectives: Assess the impact of insulin therapy on achieving the target blood glucose and glycated hemoglobin (HbA1c) levels. Examine the long-term effects of combining insulin therapy with oral hypoglycaemic agents on cardiovascular outcomes and overall mortality. Evaluate patient adherence to insulin therapy, considering factors influencing compliance such as dosing regimen, injection technique, and lifestyle adjustments.
Results: The study involved 350 patients (183 females and 167 males) receiving various diabetes treatments: 230 on oral hypoglycaemics, 23 on
insulin, and 68 on a combination of therapies. A significant HbA1c reduction from 7.71% to 5.33% was observed. Mean FBS, post-FBS, and PPBS were
166.57, 172.86, and 248.57 mg/dL, indicating improved glycaemic control.
Conclusion: This study highlights the need for improved strategies to enhance compliance and adherence to treatment, address social habits, and
manage weight effectively. By optimizing insulin therapy alongside oral hypoglycaemics, healthcare providers can significantly improve glycaemic
control and overall health outcomes in patients with uncontrolled T2D. Keywords: Type 2 diabetes, insulin, oral hypoglycaemic drugs, adherence.
