{"id":2076,"date":"2026-04-17T06:50:43","date_gmt":"2026-04-17T06:50:43","guid":{"rendered":"https:\/\/diabetesasia.org\/journal\/?p=2076"},"modified":"2026-04-22T09:26:03","modified_gmt":"2026-04-22T09:26:03","slug":"safety-and-efficacy-of-different-classes-of-insulin-as-add-on-therapy-of-oral-hypoglycemic-agents-in-uncontrolled-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/www.diabetesasia.org\/journal\/safety-and-efficacy-of-different-classes-of-insulin-as-add-on-therapy-of-oral-hypoglycemic-agents-in-uncontrolled-type-2-diabetes\/","title":{"rendered":"Safety and Efficacy of different Classes of Insulin as Add on Therapy of oral hypoglycemic agents in uncontrolled Type 2 Diabetes"},"content":{"rendered":"\n<p><strong>Safety and Efficacy of different Classes of Insulin as Add on Therapy of oral hypoglycemic agents in uncontrolled Type 2 Diabetes<\/strong><\/p>\n\n\n\n<p>Ashritha Kudikala<sup>1<\/sup>, Haripriya Kanaparthi, Mahibul Islam<sup>1<\/sup>, Satish Chinnala<sup>2<\/sup><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Pharm.D Intern, Balaji Institute of Pharmaceutical Sciences, Laknepally, Warangal, Narsampet, India; 2. Associate Professor, Department of Clinical<br>Pharmacy, Balaji Institute of Pharmaceutical Sciences, Laknepally, Warangal, Narsampet, India. (Corresponding author)<br>kudikalaashritha@gmail.com<\/li>\n<\/ol>\n\n\n\n<p><strong>Abstract<\/strong><\/p>\n\n\n\n<p><strong>Aim<\/strong>: This study aims to evaluate the safety and efficacy of insulin as an adjunct therapy to one or More oral hypoglycaemic agents in patients with<br>uncontrolled type 2 diabetes (T2D).<br><strong>Objectives: <\/strong>Assess the impact of insulin therapy on achieving the target blood glucose and glycated hemoglobin (HbA1c) levels. Examine the long-term effects of combining insulin therapy with oral hypoglycaemic agents on cardiovascular outcomes and overall mortality. Evaluate patient adherence to insulin therapy, considering factors influencing compliance such as dosing regimen, injection technique, and lifestyle adjustments.<br><strong>Results<\/strong>: The study involved 350 patients (183 females and 167 males) receiving various diabetes treatments: 230 on oral hypoglycaemics, 23 on<br>insulin, and 68 on a combination of therapies. A significant HbA1c reduction from 7.71% to 5.33% was observed. Mean FBS, post-FBS, and PPBS were<br>166.57, 172.86, and 248.57 mg\/dL, indicating improved glycaemic control.<\/p>\n\n\n\n<p><strong>Conclusion<\/strong>: This study highlights the need for improved strategies to enhance compliance and adherence to treatment, address social habits, and<br>manage weight effectively. By optimizing insulin therapy alongside oral hypoglycaemics, healthcare providers can significantly improve glycaemic<br>control and overall health outcomes in patients with uncontrolled T2D. Keywords: Type 2 diabetes, insulin, oral hypoglycaemic drugs, adherence.<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/diabetesasia.org\/journal\/wp-content\/uploads\/2026\/04\/Vol-3-Issue-1-oha.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Vol 3 Issue 1 oha.\"><\/object><a id=\"wp-block-file--media-0147aa67-413d-4e32-a70f-822430a0fd82\" href=\"https:\/\/diabetesasia.org\/journal\/wp-content\/uploads\/2026\/04\/Vol-3-Issue-1-oha.pdf\">Vol 3 Issue 1 oha<\/a><a href=\"https:\/\/diabetesasia.org\/journal\/wp-content\/uploads\/2026\/04\/Vol-3-Issue-1-oha.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-0147aa67-413d-4e32-a70f-822430a0fd82\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Safety and Efficacy of different Classes of Insulin as Add on Therapy of oral hypoglycemic agents in uncontrolled Type 2 Diabetes Ashritha Kudikala1, Haripriya Kanaparthi, Mahibul Islam1, Satish Chinnala2 Abstract Aim: This study aims to evaluate the safety and efficacy of insulin as an adjunct therapy to one or More oral hypoglycaemic agents in patients withuncontrolled type 2 diabetes (T2D).Objectives: Assess the impact of insulin therapy on achieving the target blood glucose and glycated hemoglobin (HbA1c) levels. Examine the long-term effects of combining insulin therapy with oral hypoglycaemic agents on cardiovascular outcomes and overall mortality. Evaluate patient adherence to insulin therapy, considering factors influencing compliance such as dosing regimen, injection technique, and lifestyle adjustments.Results: The study involved 350 patients (183 females and 167 males) receiving various diabetes treatments: 230 on oral hypoglycaemics, 23 oninsulin, and 68 on a combination of therapies. A significant HbA1c reduction from 7.71% to 5.33% was observed. Mean FBS, post-FBS, and PPBS were166.57, 172.86, and 248.57 mg\/dL, indicating improved glycaemic control. Conclusion: This study highlights the need for improved strategies to enhance compliance and adherence to treatment, address social habits, andmanage weight effectively. By optimizing insulin therapy alongside oral hypoglycaemics, healthcare providers can significantly improve glycaemiccontrol and overall health outcomes in patients with uncontrolled T2D. Keywords: Type 2 diabetes, insulin, oral hypoglycaemic drugs, adherence.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[134,135],"tags":[65,54],"class_list":["post-2076","post","type-post","status-publish","format-standard","hentry","category-vol-3-issue-1-april-2026","category-vol-3-issue-1","tag-insulin","tag-type-2-diabetes"],"_links":{"self":[{"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts\/2076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/comments?post=2076"}],"version-history":[{"count":0,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts\/2076\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/media?parent=2076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/categories?post=2076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/tags?post=2076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}