{"id":5000,"date":"2026-06-02T07:19:35","date_gmt":"2026-06-02T07:19:35","guid":{"rendered":"https:\/\/www.diabetesasia.org\/journal\/?p=5000"},"modified":"2026-06-02T11:10:48","modified_gmt":"2026-06-02T11:10:48","slug":"medical-nutrition-therapy-metformin-in-early-gestational-glucose-intolerance-to-preventpost-partum-diabetes-risk-in-a-hospital-prospective-study","status":"publish","type":"post","link":"https:\/\/www.diabetesasia.org\/journal\/medical-nutrition-therapy-metformin-in-early-gestational-glucose-intolerance-to-preventpost-partum-diabetes-risk-in-a-hospital-prospective-study\/","title":{"rendered":"Medical Nutrition Therapy &#038; Metformin in Early Gestational Glucose Intolerance to PreventPost-Partum Diabetes Risk in a hospital Prospective Study"},"content":{"rendered":"\n<p>Medical Nutrition Therapy &amp; Metformin in Early Gestational Glucose Intolerance to Prevent<br>Post-Partum Diabetes Risk in a Hospital Prospective Study<\/p>\n\n\n\n<p>Shweta Verma*1, Renu Gupta2, Neena Gupta3, Divya Dwivedi4 , Palak Taneja5<\/p>\n\n\n\n<p>Submitted: 10 Dec 2025; Accepted: 25 Dec 2025; Published: 10 Jan 2026<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>Objectives<br>This study examines how Medical Nutrition Therapy (MNT) and Metformin help manage early gestational glucose intolerance<br>during the 8th-10th weeks of pregnancy, particularly when postprandial blood glucose (PPBG) is &gt;110 mg\/dL. The goal is to<br>find out if these treatments can prevent gestational diabetes mellitus (GDM) and lower the risk of diabetes after pregnancy.<br>Material and Methods<br>A prospective cohort study was conducted at the GSVM Medical Hospital in Kanpur, involving approximately 231 pregnant women<br>at 8 to 10 weeks of gestation with pre-prandial blood glucose (PPBG) levels of at least 110 mg\/dL. Participants were randomly<br>assigned to either the MNT-Metformin group, receiving dosages ranging from 500 to 2500 mg, or the MNT-only group.<br>Results<br>At 2 to 3 days postpartum and at 6 weeks, the mean PPBG for the Metformin plus MNT group was 106.9 \u00b1 5.24 mg\/dL and<br>107.51 \u00b1 10.67 mg\/dL, respectively (P = 0.57). The mean HBA1c values were 4.84 \u00b1 0.20 and 4.99 \u00b1 0.37, respectively, with a P-value<br>&lt; 0.05.<br>Conclusion<br>Early detection and management of early gestational glucose intolerance (EGGI) with medical nutrition therapy (MNT) and<br>Metformin can reduce the risk of progression to diabetes during postpartum screening.<\/p>\n\n\n\n<p><br>Keywords: EGGI Early gestational glucose intolerance, Gestational diabetes mellitus (GDM), PPBG: Postprandial blood<br>glucose, MNT Medical Nutrition Therapy, OGCT Oral Glucose Challenge Test, DIPSI diabetes in Pregnancy Study Group India.<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/www.diabetesasia.org\/journal\/wp-content\/uploads\/2026\/06\/Shweta-MNT-Metformin-Post-partum-study.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Shweta MNT Metformin Postpartum study.\"><\/object><a id=\"wp-block-file--media-72242e91-4ff8-428e-a89f-c690f6d21a21\" href=\"https:\/\/www.diabetesasia.org\/journal\/wp-content\/uploads\/2026\/06\/Shweta-MNT-Metformin-Post-partum-study.pdf\">Shweta MNT Metformin Postpartum study<\/a><a href=\"https:\/\/www.diabetesasia.org\/journal\/wp-content\/uploads\/2026\/06\/Shweta-MNT-Metformin-Post-partum-study.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-72242e91-4ff8-428e-a89f-c690f6d21a21\">Download<\/a><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Medical Nutrition Therapy &amp; Metformin in Early Gestational Glucose Intolerance to PreventPost-Partum Diabetes Risk in a Hospital Prospective Study Shweta Verma*1, Renu Gupta2, Neena Gupta3, Divya Dwivedi4 , Palak Taneja5 Submitted: 10 Dec 2025; Accepted: 25 Dec 2025; Published: 10 Jan 2026 Abstract ObjectivesThis study examines how Medical Nutrition Therapy (MNT) and Metformin help manage early gestational glucose intoleranceduring the 8th-10th weeks of pregnancy, particularly when postprandial blood glucose (PPBG) is &gt;110 mg\/dL. The goal is tofind out if these treatments can prevent gestational diabetes mellitus (GDM) and lower the risk of diabetes after pregnancy.Material and MethodsA prospective cohort study was conducted at the GSVM Medical Hospital in Kanpur, involving approximately 231 pregnant womenat 8 to 10 weeks of gestation with pre-prandial blood glucose (PPBG) levels of at least 110 mg\/dL. Participants were randomlyassigned to either the MNT-Metformin group, receiving dosages ranging from 500 to 2500 mg, or the MNT-only group.ResultsAt 2 to 3 days postpartum and at 6 weeks, the mean PPBG for the Metformin plus MNT group was 106.9 \u00b1 5.24 mg\/dL and107.51 \u00b1 10.67 mg\/dL, respectively (P = 0.57). The mean HBA1c values were 4.84 \u00b1 0.20 and 4.99 \u00b1 0.37, respectively, with a P-value&lt; 0.05.ConclusionEarly detection and management of early gestational glucose intolerance (EGGI) with medical nutrition therapy (MNT) andMetformin can reduce the risk of progression to diabetes during postpartum screening. Keywords: EGGI Early gestational glucose intolerance, Gestational diabetes mellitus (GDM), PPBG: Postprandial bloodglucose, MNT Medical Nutrition Therapy, OGCT Oral Glucose Challenge Test, DIPSI diabetes in Pregnancy Study Group India.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,126],"tags":[10,8,42,109],"class_list":["post-5000","post","type-post","status-publish","format-standard","hentry","category-blog","category-vol-2-issue-4","tag-dipsi","tag-eggi","tag-gdm","tag-metformin"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts\/5000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/comments?post=5000"}],"version-history":[{"count":3,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts\/5000\/revisions"}],"predecessor-version":[{"id":5008,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/posts\/5000\/revisions\/5008"}],"wp:attachment":[{"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/media?parent=5000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/categories?post=5000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.diabetesasia.org\/journal\/wp-json\/wp\/v2\/tags?post=5000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}