Omicron Linked to an Immunocompromised Patient?
Dec. 3, 2021 — Facing a new surge in COVID-19 cases and the arrival of the Omicron variant, German leaders on Thursday put into place new restrictions on unvaccinated people.
People who are not vaccinated are barred from all. Still, a few important businesses, such as supermarkets and pharmacies, outgoing Chancellor Angela Merkel and her successor, Olaf Scholz, announced at a news conference.
Other restrictions could be imposed, depending on a region’s hospitalization rate.
Merkel and Scholz said that the national legislature will vote in 2022 to make COVID vaccinations mandatory for Germans.
“The situation is dire,” Merkel said. “The number of infections has stabilized, but on a far too high a level.”
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About 69% of Germany’s population is fully vaccinated – one of the lowest rates in western Europe, DW said.
The number of COVID-related deaths is lower than last winter, but the current number of infections is higher. About 74,000 new cases were reported Thursday.
However, there are signs the surge is flattening, with the daily seven-day rate dropping for the third straight day to 439.2 per 100,000 residents, DW said.
Scholz will become chancellor this week. Merkel has led the nation since 2005.
Neighboring Austria approved similar restrictions last month.
The Omicron variant, spreading now in southern Africa and detected in over 30 other countries, has prompted fears that it could significantly undermine vaccines’ effectiveness against COVID-19.
Yet, as scientists race to understand the full consequences of Omicron, some are also asking whether this new version of coronavirus might cause milder illness than its predecessors. While they caution that it is far too early to conclude, here is what is known so far:
What Do The Data Show?
Evidence from initial cases of the new variant is limited.
According to a report on Thursday by the European Center for Disease Prevention and Control, among 70 cases reported in Europe that included information on disease severity, half of the patients had no symptoms, and half had mild symptoms.
There were no cases of severe disease, hospitalization, or death. However, the European agency said it would require data on hundreds of cases to accurately assess disease complications, estimating that could take several weeks. In addition, most cases detected in Europe so far have been in younger people who were fully vaccinated, making them less likely to suffer severe illness.
In South Africa, where the daily number of reported COVID-19 cases doubled on Wednesday to 8,561, symptoms for reinfected patients and those infected after vaccination appear to be mild.
“Some evidence from South Africa suggests that it may cause more mild illness but. I caution you that a lot of the patients in South Africa initially were among young university students,” Dr. Carlos Del Rio, an infectious diseases expert at Emory University in Atlanta, said on Thursday during an online briefing from the Infectious Diseases Society of America.
Is Omicron A ‘Less Fit’ Version Of Coronavirus?
While data on real-world infections continues to emerge, scientists conduct laboratory studies to decipher Omicron. The variant has about 50 mutations not seen in combination before, including more than 30 mutations on the coronavirus spike protein to attach to human cells. Vaccines in current use target that spike protein.
“Typically, when viruses accumulate a lot of mutations, they lose some fitness,” said Dr. John Wherry, director of the Penn Institute for Immunology in Philadelphia. Specific Omicron mutations may impair the ability of the virus to cleave, changing the behavior of the spike protein, he said.
Some scientists have theorized Omicron may have developed for months in an immunocompromised individual, such as an HIV patient in southern Africa. If so, “the virus adapted not to kill that host,” Wherry said.
There are competing theories that the latest variant evolved from an animal host.
Will Omicron Become The Dominant Variant?
The other central question surrounding Omicron is whether it will overtake the Delta variant, which still accounts for most known infections worldwide. Suppose Omicron does become dominant but causes milder illness. In that case, it could mark a turning point toward the virus eventually becoming a seasonal threat, like influenza, said Sumit Chanda, an infectious disease researcher at the Scripps Research Department of Immunology and Microbiology in San Diego.
The European Union’s public health agency said the Omicron variant could be responsible for more than half of all COVID-19 infections in Europe within a few months.
While the research into Omicron is underway, disease experts say people must remain vigilant against the coronavirus by getting either initial vaccinations or booster shots and wearing masks in indoor or crowded settings, ventilating rooms, and washing hands.
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